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Tapentadol is an opioid pain-relief medicine that is prescribed for relief of severe paintapentadol hydrochloride tablets

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What is tapentadol?

Tapentadol is an opioid medicine your doctor can prescribe to treat severe pain, only available with a prescription from your doctor.

An opioid is sometimes called a narcotic. Tapentadol is a prescription medicine that is used to treat moderate to severe pain.

Tapentadol extended-release form (Nucynta ER) is for around-the-clock treatment of pain that is not controlled by other medicines. The extended-release form of tapentadol is not for use on an as-needed basis for pain.

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tapentadol hydrochloride 100mg tablets

What forms of tapentadol are available?

Tapentadol is available as an oral tablet.

Some forms of tapentadol are ‘immediate-release’ (known as IR), meaning they start working straight away and their effects wear off more quickly. Others are ‘controlled-release’ (also called ‘sustained release’ or SR), which means that their effect is spread out over a longer period of time.

Why is tapentadol prescribed?

Tapentadol immediate-release tablets are used as short-term treatment to relieve moderate to severe acute pain (pain that begins suddenly, has a specific cause, and is expected to go away when the cause of the pain is healed) that cannot be controlled by the use of alternative pain medications in adults and children 6 years of age and older who weigh at least 88 lb (40 kg).

Tapentadol extended-release tablets are used to relieve severe (around-the-clock) pain that cannot be controlled by the use of other pain medications.

Tapentadol extended-release tablets are also used to relieve severe (around-the-clock) neuropathic pain (pain caused by nerve damage) that cannot be controlled by the use of other pain medications.in people who have diabetes.

Tapentadol extended-release tablets should not be used to treat pain that can be controlled by medication that is taken as needed.. Tapentadol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

How should I take tapentadol?

Take tapentadol exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides. Never use tapentadol in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of tapentadol.

Never share opioid medicine with another person, especially someone with a history of drug addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law.

Stop taking all other medications that contain tapentadol or tramadol when you start taking tapentadol extended-release tablets.

Take tapentadol with a full glass of water at the same times each day, with or without food.

Do not crush, break, or open an extended-release pill. Swallow it whole to avoid exposure to a potentially fatal dose.

Tapentadol can cause constipation. Talk to your doctor before using a laxative or stool softener to treat or prevent this side effect.

Never crush a pill to inhale the powder or inject it into your vein. This could result in death.

You may have withdrawal symptoms if you stop using tapentadol suddenly. Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, flush the unused medicine down the toilet.

what side effects can Tapentadol cause ?

Tapentadol may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
  • headache
  • heartburn
  • stomach pain
  • dry mouth
  • excessive tiredness
  • anxiety
  • drowsiness
  • difficulty falling asleep or staying asleep
  • abnormal dreams
  • irritability
  • sudden feeling of warmth
Some side effects can be serious. If you experience any of these symptoms or those listed in the SPECIAL PRECAUTIONS or IMPORTANT WARNING sections, call your doctor immediately or get emergency medical treatment:
  • seizures
  • agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea
  • nausea, vomiting, loss of appetite, weakness, or dizziness
  • inability to get or keep an erection
  • irregular menstruation
  • decreased sexual desire
  • rash
  • itching
  • hives
  • swelling of the eyes, face, lips, tongue, or throat
  • hoarseness
  • difficulty breathing or swallowing
  • chest pain
  • feeling lightheaded when you change positions
  • feeling faint
  • loss of consciousness
  • feeling overheated
  • heavy sweating
  • worsening pain, increased sensitivity to pain, or new pain, especially after taking tapentadol

Tapentadol may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What other drugs will affect tapentadol?

Many other drugs can be dangerous when used with opioid medicine. Tell your doctor if you also use:

  • medicine for allergies, asthma, blood pressure, motion sickness, irritable bowel, or overactive bladder;
  • other opioid medicines;
  • a benzodiazepine sedative like Valium, Klonopin, or Xanax;
  • sleep medicine, muscle relaxers, or other drugs that make you drowsy; or
  • drugs that affect serotonin, such as antidepressants, stimulants, or medicine for migraines or Parkinson’s disease.

This list is not complete. Many drugs may interact with tapentadol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.


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Tapentadol is an opioid pain-relief medicine that is prescribed for relief of severe pain, where other pain medicines have not been effective or cannot be used.

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