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Tilidin AL comp 200mg improved

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Tilidin AL comp  is used in severe pains related to malignant diseases

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What Is Tilidin Al Comp

Tilidin AL comp  is used in severe pains related to malignant diseases; spastic states, associated with severe pain originating from the gastrointestinal tract, urinary and biliary tracts; postoperative pain, neuralgia, and particularly neuralgia of the trigeminal nerve.

How does Tilidin Al  comp works

Tilidine is rapidly absorbed after oral administration and is subject to a pronounced first-pass effect.

The conversion of tilidine into the more active metabolite nortilidine occurs with the participation of CYP3A4 and CYP2C19. The inhibition of these enzymes can thus alter the efficacy and tolerability profile of tilidine. The analgesic effect occurs after 10–15 minutes.

After oral administration of 100 mg tilidine plus 8 mg naloxone, the maximum effect is reached in about 25–50 minutes. The duration of action is given as 4-6 hours.

The elimination half-life for nortilidine is 3–5 hours. Tilidine is metabolised to 90% and eliminated renally. The rest appears in the faeces.

Depending on the extent of the impairment, the maximum concentration of nortilidine in plasma is lower in insufficient liver function than in healthy individuals and the half-life is prolonged.

In case of severe hepatic insufficiency the therapy is questionable. In these cases, it is possible that the formation of active nortilidine may be so low that the analgesic effect is insufficient. In addition, in the combination preparations with naloxone, the inactivation of the same can only be insufficient.

The consequent antagonisation of the nortilidine effect can lead to a further loss of activity.

this drug augments the central depressive action of alcohol, analeptics, analgesic agents, barbiturates, and tranquilizers

What are the side effects of Tilidin Al Comp

  1. Headache
  2. dizziness
  3. orthostatic
  4. collapse
  5. nausea
  6. vomiting

Medical uses of Tilidin Al comp

tilidin Al comp
Tilidine

Tilidine is used in the form of hydrochloride or phosphate salt. In Germany, tilidine is available in a fixed combination with naloxone for oral administration (Valoron N and generics); the mixture of naloxone is claimed to lower the abuse liability of the opioid analgesic.

This is so that if people take the medication orally (which is the way they are meant to) the opioid blocker, naloxone, has minimal effects on them but if they inject it the naloxone becomes bioavailable and hence antagonises the effects of the tilidine producing withdrawal effects. In Switzerland the original Valoron brand with only tilidine and no naloxone is also available.

As well as its use as an analgesic, tilidine is also commonly used in Germany for treatment of restless legs syndrome. The reversed ester is also known and is also a prodrug.

Tilidine is a controlled substance in most countries, listed in the German BtMG, Austrian SMG, and in the USA under the Controlled Substances Act 1970 as ACSCN 9750 as a Narcotic under Schedule I, with an annual aggregate manufacturing quota of 10 grams in 2014. It is used as the hydrochloride (free base conversion ratio 0.882) and HCl hemihydrate (

What are common symptoms of tilidine overdose?

Tilidine overdose can cause serious symptoms such as shortness of breath, unconsciousness, and cardiac arrest. If you suspect that you have experienced a Tilidine overdose, you should seek medical attention right away or call 911.

How to avoid dependence on tilidine?

To avoid dependence on tilidine, the drug should be taken only as long as prescribed. It is also important not to increase the dose or shorten the time of intake. If you feel that you are addicted to tilidine, you should contact a doctor or therapist for help.

How is tilidine taken?

Tilidine is taken orally, as a tablet or drops. There is also a solid, sustained release (retard) tablet. The dosage depends on the severity of the pain and should always be prescribed by a doctor or pharmacist. It is important not to increase the dose or shorten the time of intake to avoid dependence or overdose.

Buy Tilidin AL comp 200mg/16mg

Buy Tilidin AL comp .Tilidine, or tilidate (brand names: TilidinValoron and Valtran) is a synthetic opoid painkiller, used mainly in Belguim, Bulgaria, Germany, Luxembourg, South Africa and Switzerland for the treatment of moderate to severe pain, both acute and chronic.

Its onset of pain relief after oral administration is about 10–15 minutes and peak relief from pain occurs about 25–50 minutes after oral administration.

Tilidine is used in the form of hydrochlride or phosphate salt. In Germany, tilidine is available in a fixed combination with naloxone for oral administration (Valoron N and generics); the mixture of naloxone is claimed to lower the abuse liability of the opioid analgesic.

This is so that if people take the medication orally (which is the way they are meant to) the opioid blocker, naloxone, has minimal effects on them but if they inject it the naloxone becomes bioavailable and hence antagonises the effects of the tilidine producing withdrawal effects. In Switzerland the original Valoron brand with only tilidine and no naloxone is also available. 

As well as its use as an analgesic, tilidine is also commonly used in Germany for treatment of restless leg syndrome. The reversed ester is also known and is also a prodrug. Buy Tilidin AL comp 200MG/16mg HERE

Tilidin AL comp
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Tilidin dosage

The required dose is determined individually by the doctor depending on the pain level and the patient’s individual response. The daily dose can be between 100 mg and a maximum of 600 mg (based on tilidine hydrochloride ).

Tilidine is available in combination with naloxone in various dosage forms in the following dosages:

Prolonged-release tablets (tilidine hydrochloride/ naloxone hydrochloride ):

  • 50mg/4mg
  • 100mg/8mg
  • 150mg/12mg
  • 200mg/16mg.

Drops/Oral Solution (Tilidine Hydrochloride/Naloxone Hydrochloride):

  • 50 mg/4 mg (per 20 drops or 4 pumps).

Interactions

Concomitant use of serotonergic drugs may increase the risk of serotonin syndrome, a potentially life-threatening condition. These include, for example:

  • selective serotonin reuptake inhibitors (SSRIs)
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs)
  • tricyclic antidepressants
  • Triptans
  • 5-HT3 receptor antagonists
  • Drugs that affect the serotonin neurotransmitter system (e.g. mirtazapine , trazodone , tramadol )
  • Monoamine oxidase (MAO) inhibitors.

Under the influence of alcohol or in conjunction with sedatives, the effects on the central nervous system are mutually reinforced and prolonged.

CYP3A4 and/or CYP2C19 inhibitors (e.g. voriconazole ) may result in significant increases in tilidine exposure and increases in nortilidine concentrations. Intensification of the analgesic effect is possible with a simultaneous risk of respiratory depression.

A drop in the Quick value is possible during long-term anticoagulation with phenprocoumon . The prothrombin time should therefore be closely monitored, particularly at the beginning and end of treatment with tilidine. If necessary, the phenprocoumon dose can be adjusted.

Contraindication

Tilidine must not be used in:

  • Hypersensitivity to the active ingredient
  • Dependence on opiates ( heroin , morphine ) or opioids.

It should also not be taken if you have other addictions or if you have porphyria.

In cases of severe liver insufficiency (e.g. severe liver cirrhosis), reduced hepatic metabolism can lead to a loss of effectiveness of tilidine.

Pregnancy/breastfeeding

Tilidine should not be given during pregnancy or only after the strictest benefit-risk assessment, as there is no or only limited experience in humans.

Tilidine passes into breast milk. Therefore, breastfeeding should be discontinued if treatment during breastfeeding is absolutely necessary.

Data on the effects of tilidine on human fertility are not available. Animal studies did not provide any evidence of adverse health effects on male and female fertility.

Driving ability

Tilidine can impair attention and reactions and thus the ability to actively participate in traffic or operate machines.

Increased impairment is to be expected, particularly when starting treatment, increasing the dose, changing medication or in combination with alcohol or sedatives. A general driving ban is not absolutely necessary if treatment is stable.

Further details about this active ingredient can be found in the relevant specialist information.

Active ingredient information

Molar mass:
273.37 g mol -1
Mean half-life:
approx. 3.3 H
Q0 value:
0.95

How To Order Tilidin online without prescription

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You will then be requested to choose your payment option. We will contact you with the payment details and once the payment is done, we will dispatch your order and send you a tracking number.

Buy Generic Tilidin Online

Many people having severe pains and  are wondering where to buy tilidin online since it’s not that easy to get a prescription.

We let you buy cheap tilidin online  HERE without prescription because we know not everybody has a prescription for their drugs, and we understand the meaning of you wanting to get some drugs to calm you down.

WHY ORDER FROM US

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quantity

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2 reviews for Tilidin AL comp 200mg improved

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1-2 of 2 reviews
  1. have tried some other pain relief meds , but tilidin works best and more efficient . i wasn’t sure about the quality till i had taken them. the quality and packaging was good . i’ll like you guys to improve on delivery time . thanks for the discount.

  2. thanks for the discount mate. my order arrived yesterday .

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