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Xanax (alprazolam) is used as an anti-anxiety prescribed to treat panic attacks and anxiety disorders.

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What Is Xanax?

Xanax (alprazolam) is a benzodiazepine used as an anti-anxiety medication prescribed to treat panic attacks and anxiety disorders. Xanax is available in generic form.

XANAX Tablets contain alprazolam which is a triazolo analog of the 1,4 benzodiazepine class of central nervous system-active compounds.

The chemical name of alprazolam is 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo [4,3-α] [1,4] benzodiazepine.

 

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Alprazolam is a white crystalline powder, which is soluble in methanol or ethanol but which has no appreciable solubility in water at physiological pH.

Each XANAX Tablet, for oral administration, contains 0.25, 0.5, 1 or 2 mg of alprazolam.

XANAX Tablets, 2 mg, are multi-scored and may be divided as shown below

The structural formula is represented to the right:

XANAX® (alprazolam) - Structural Formula Illustration

 

XANAX® tablets - Structural Formula Illustration 2

 

Why is Xanax 2mg a drug of this kind?

Xanax 2mg is a prescription drug for people with anxiety and panic disorders. The main use of the drug in the treatment of such psychological disorders can be seen in its efficacy.

The medication provides a calming effect on the person, which allows him to take responsibility for his / her emotions and behavior, thus saving them from extreme anxiety attacks.

Medicine is a benzodiazepine, however, which means that it must be administered with the utmost care and under the close supervision of a medical professional so that the causes of addiction can be prevented.

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Storage And Handling

XANAX is supplied in the following strengths and package configurations:

 

 

XANAX Tablets
Package ConfigurationTablet Strength (mg)NDCPrint
Bottles of 100 Reverse Numbered0.25 mgNDC 0009-0029-01white, oval, scored, imprinted “XANAX 0.25”
Unit dose (100)NDC 0009-0029-46
Bottles of 500NDC 0009-0029-02
Bottles of 1000NDC 0009-0029-14
Bottles of 1000.5 mgNDC 0009-0055-01peach, oval, scored, imprinted “XANAX 0.5”
Reverse Numbered Unit dose (100)NDC 0009-0055-46
Bottles of 500NDC 0009-0055-03
Bottles of 1000NDC 0009-0055-15
Bottles of 1001 mgNDC 0009-0090-01blue, oval, scored, imprinted “XANAX 1.0”
Bottles of 500NDC 0009-0090-04
Bottles of 1000NDC 0009-0090-13
Bottles of 1002 mgNDC 0009-0094-01white, oblong, multi-scored, imprinted “XANAX” on one side and “2” on the reverse side
Bottles of 500NDC 0009-0094-03

 

What Are Side Effects of Xanax?

Xanax may cause serious side effects including:

  • depressed mood,
  • thoughts of suicide or hurting yourself,
  • racing thoughts,
  • increased energy,
  • unusual risk-taking behavior,
  • confusion,
  • agitation,
  • hostility,
  • hallucinations,
  • uncontrolled muscle movements,
  • tremor,
  • convulsions (seizure), and
  • pounding heartbeats or fluttering in your chest

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Xanax include:

  • Drowsiness
  • Tiredness
  • Dizziness
  • Sleep problems (insomnia)
  • Memory problems
  • Poor balance or coordination
  • Slurred speech
  • Trouble concentrating
  • Irritability
  • Diarrhea
  • Constipation
  • Increased sweating
  • Headache
  • Nausea
  • Vomiting
  • Upset stomach
  • Blurred vision
  • Appetite or weight changes
  • Swelling in your hands or feet
  • Muscle weakness
  • Dry mouth
  • Stuffy nose
  • Loss of interest in sex

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Xanax

Treatment for patients with anxiety should be initiated with a dose of 0.25 to 0.5 mg Xanax given three times daily. Treatment of many panic disorders in patients has required the use of Xanax at doses greater than 4 mg daily.

What Drugs, Substances, or Supplements Interact with Xanax?

Xanax may interact with alcohol, other medicines that make you sleepy (such as cold or allergy medicine, other sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety),

birth control pills

cimetidine,

cyclosporine,

dexamethasone,

ergotamine,

imatinib,

isoniazid,

St. John’s wort,

antibiotics,

antifungals,

antidepressants,

barbiturates,

heart or blood pressure medications,

HIV/AIDS medicines,

seizure medications.

Tell your doctor all medications and supplements you use.

Xanax During Pregnancy and Breastfeeding

Benzodiazepines, such as Xanax, can cause fetal abnormalities and should not be used in pregnancy or in nursing mothers. Xanax is excreted in human milk and can affect nursing infants. Breastfeeding while taking Xanax is not recommended.

Additional Information

Our Xanax Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

 

DOSAGE AND ADMINISTRATION

Dosage In Generalized Anxiety Disorder

The recommended starting oral dosage of XANAX for the acute treatment of patients with GAD is 0.25 mg to 0.5 mg administered three times daily. Depending upon the response, the dosage may be adjusted at intervals of every 3 to 4 days. The maximum recommended dosage is 4 mg daily (in divided doses).

Use the lowest possible effective dose and frequently assess the need for continued treatment [see WARNINGS AND PRECAUTIONS].

Dosage In Panic Disorder

The recommended starting oral dosage of XANAX for the treatment of PD is 0.5 mg three times daily. Depending on the response, the dosage may be increased at intervals of every 3 to 4 days in increments of no more than 1 mg per day.

Controlled trials of XANAX in the treatment of panic disorder included dosages in the range of 1 mg to 10 mg daily. The mean dosage was approximately 5 mg to 6 mg daily. Occasional patients required as much as 10 mg per day.

For patients receiving doses greater than 4 mg per day, periodic reassessment and consideration of dosage reduction is advised. In a controlled postmarketing dose-response study, patients treated with doses of XANAX greater than 4 mg per day for 3 months were able to taper to 50% of their total maintenance dose without apparent loss of clinical benefit.

The necessary duration of treatment for PD in patients responding to XANAX is unknown. After a period of extended freedom from panic attacks, a carefully supervised tapered discontinuation may be attempted, but there is evidence that this may often be difficult to accomplish without recurrence of symptoms and/or the manifestation of withdrawal phenomena [see Discontinuation Or Dosage Reduction Of XANAX].

Discontinuation Or Dosage Reduction Of XANAX

To reduce the risk of withdrawal reactions, use a gradual taper to discontinue XANAX or reduce the dosage. If a patient develops withdrawal reactions, consider pausing the taper or increasing the dosage to the previous tapered dosage level. Subsequently decrease the dosage more slowly [see WARNINGS AND PRECAUTIONSDrug Abuse And Dependence].

Reduced the dosage by no more than 0.5 mg every 3 days. Some patients may benefit from an even more gradual discontinuation. Some patients may prove resistant to all discontinuation regimens.

In a controlled postmarketing discontinuation study of panic disorder patients which compared the recommended taper schedule with a slower taper schedule, no difference was observed between the groups in the proportion of patients who tapered to zero dose; however, the slower schedule was associated with a reduction in symptoms associated with a withdrawal syndrome.

Dosage Recommendations In Geriatric Patients

In geriatric patients, the recommended starting oral dosage of XANAX is 0.25 mg, given 2 or 3 times daily. This may be gradually increased if needed and tolerated. Geriatric patients may be especially sensitive to the effects of benzodiazepines. If adverse reactions occur at the recommended starting dosage, the dosage may be reduced [see Use In Specific PopulationsCLINICAL PHARMACOLOGY].

Dosage Recommendations In Patients With Hepatic Impairment

In patients with hepatic impairment, the recommended starting oral dosage of XANAX is 0.25 mg, given 2 or 3 times daily. This may be gradually increased if needed and tolerated. If adverse reactions occur at the recommended starting dose, the dosage may be reduced [see Use In Specific PopulationsCLINICAL PHARMACOLOGY].

Dosage Modifications For Drug Interactions

XANAX should be reduced to half of the recommended dosage when a patient is started on ritonavir and XANAX together, or when ritonavir administered to a patient treated with XANAX. Increase the XANAX dosage to the target dose after 10 to 14 days of dosing ritonavir and XANAX together. It is not necessary to reduce XANAX dose in patients who have been taking ritonavir for more than 10 to 14 days.

XANAX is contraindicated with concomitant use of all strong CYP3A inhibitors, except ritonavir [see CONTRAINDICATIONSWARNINGS AND PRECAUTIONS].

HOW SUPPLIED

Dosage Forms And Strengths

XANAX tablets are available as:

  • 0.25 mg: white, oval, scored, imprinted “XANAX 0.25”
  • 0.5 mg: peach, oval, scored, imprinted “XANAX 0.5”
  • 1 mg: blue, oval, scored, imprinted “XANAX 1.0”
  • 2 mg: white, oblong, multi-scored, imprinted “XANAX ” on one side and “2” on the reverse side

Warnings

Xanax can slow or stop your breathing, especially if you have recently used an opioid medication or alcohol.

MISUSE OF XANAX CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Do not stop using Xanax without asking your doctor. You may have life-threatening withdrawal symptoms if you stop using the medicine suddenly after long-term use. Some withdrawal symptoms may last up to 12 months or longer.

Get medical help right away if you stop using Xanax and have symptoms such as: unusual muscle movements, being more active or talkative, sudden and severe changes in mood or behavior, confusion, hallucinations, seizures, or thoughts about suicide.

Xanax is a federal controlled substance (C-IV) because it can be abused or lead to dependence. Keep this medicine in a safe place to prevent misuse and abuse. Selling or giving away this Xanax may harm others, and is against the law. Tell your healthcare provider if you have abused or been dependent on alcohol, prescription medicines or street drugs.

Before taking this medicine

You should not take Xanax if:

  • you also take antifungal medicine such as itraconazole or ketoconazole; or
  • you have a history of allergic reaction to any benzodiazepine (alprazolam, lorazepam, diazepam, Ativan, Valium, Versed, Klonopin, and others).

To make sure Xanax is safe for you, tell your doctor if you have ever had:

  • breathing problems;
  • drug or alcohol addiction;
  • depression, mood problems, or suicidal thoughts or behavior; or
  • kidney or liver disease.

Tell your doctor if you are pregnant or plan to become pregnant. If you use Xanax during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

You should not breastfeed.

If you do breastfeed, tell your doctor if you notice drowsiness or feeding problems in the baby.

Not approved for use by anyone younger than 18 years old.

How should I take Xanax?

Take Xanax exactly as prescribed by your doctor. Follow the directions on your prescription label and read all medication guides or instruction sheets. Never use Xanax in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to use more of this medicine.

Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Swallow the Xanax XR extended-release tablet whole. Do not crush, chew, or break the tablet.

Call your doctor if your symptoms do not improve, or if they get worse.

If you use this medicine long-term, you may need frequent medical tests.

Do not stop using Xanax without asking your doctor. You may have life-threatening withdrawal symptoms if you stop using the medicine suddenly after long-term use.

Store Xanax at room temperature away from moisture, heat, and light. Keep your medicine in a place where no one can use it improperly.

Dosing information

Usual Adult Dose for Anxiety:

Immediate-release tablets: 0.25 to 0.5 mg orally administered 3 times a day
-Maximum dose: 4 mg/day

Usual Adult Dose for Panic Disorder:

Immediate-release tablets: 0.5 mg orally administered 3 times a day
-Maximum dose: 10 mg/day

Extended-release tablets:
-Initial dose: 0.5 to 1 mg orally once a day
-Maintenance dose: 3 to 6 mg orally per day, preferably in the morning
-Maximum dose: 10 mg/day

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